The association between Caveolin-1 expressions with clinicopathological characteristic of breast cancer

Introduction: Currently, prognostic determination of breast cancer often posed a challenge to oncologists due to variability in many molecular processes and metabolism. Caveolin-1 is caveolae protein that is closely related to tumour metabolism and had been proved to be associated with the level of malignancy in pre-clinical studies, but there is still no clinical evidence about Cavolin-1. Therefore, this study aimed to evaluate the association between the expressions of Caveolin-1 with clinicopathological characteristics of breast cancer. Methods: An analytical cross-sectional study was conducted in Sanglah General Hospital and Biochemistry Laboratory by using 78 subjects. The clinicopathological characteristics were recorded from medical records while Caveolin-1 expression was determined by IHC. Results: Caveolin-1 expression was found to be significantly associated with clinical stadium, subtype, histological grade and LVI in bivariate analysis. Multivariate analysis found significant only in three of them with high expression of Caveolin-1 was associated with early stadium, negative LVI and Luminal A subtype. Conclusion: Caveolin-1 expression is significantly associated with clinical stadium, LVI and subtype in breast cancer with high expression often delineate early stage, negative LVI and luminal A subtype. Keywords: Breast Cancer, Caveolin-1, Clinicopathology, Prognostic, Biomarker