Faktor risiko yang mempengaruhi pembesaran volume prostat pada pasien pembesaran prostat jinak yang dilakukan reseksi prostat transuretra

Introduction : Benign Prostate Hyperplasia (BPH) is a common degerative disease. Many contributing factors that affect benign prostatic proliferation. Many previous studies have not condudede wich factors most affecting BPH. This study is aimed at figuring out whether aging, urinary tract infection, diabetes mellitus (DM), obesity, dyslipidemia, testosterone level, TNF –? and TGF –? level in prostatic tissue is the most affecting factor to prostatic volume. Method : We conducted an analytical retrospective cohort study with data collected from the medical record. We enrolled 83 BPH Balinese patients who underwent TURP with benign histopathologic results. The baseline data were not significantly different. Bivariate analysis (Sperarman’s test) were used to find the correlation between risk factors and prostatic volume. Result: There was a positive correlation between PSA level and prostatic volume (p<0.001) and between testosterone level and prostatic volume (p=0.059), significantly moderate),. Multivariate analysis (linear regression) concluded that PSA level and testosterone level affect the prostatic volume. For every 1 ng/ml raise in PSA value, there will be 1.4 ml prostatic volume enlargement (p<0.001) and for every 1 ng/ml raise in testosterone level, there will be 0.024 ml prostatic volume enlargement (p=0.005). We concluded that PSA level and testosterone level are the most affecting factors to the prostatic volume.