The Combination Extract of Pare and Apples (APa) Reduces Risk of Atherosclerosis through Reduction of Interleukin 17 and Aggregate Focus of Liver Inflammation in High-Fat Diet

Atherosclerosis is a marked increase in IL-17 and fatty liver/ liver inflammation in a group with a high-fat diet. The study aimed to test the potential of the extract Apples Pare (APA) in reducing the risk of atherosclerosis by decreasing IL-17 and fatty liver in mice given a high-fat diet (HFD). This study used 35 mice as samples which were divided into 7 groups. K0 included mice with a normal diet; K1 mice were given HFD; P1 mice were given HFD and extract Pa; P2 mice were given the extract HFD and Ap; P3 mice were given HFD and extract APa; P4 mice were given HFD and Simvastatin; whereas P5 mice were given HFD, APa extract and Simvastatin. This study showed no fatty liver. However, there was a decrease of liver inflammation with the highest decline in a row in P5, P4, P2, P3, and final P1 than K1. This showed that the extract potentially would reduce the liver inflammation. Key Words: Extract APa, IL-17, Liver Inflammation