Pencegahan Gangguan Fungsi Ginjal Karena Stres Oksidatif pada Tikus Diabetes dengan Ubi Jalar Ungu

Recently, anthocyanins-rich food, is believed to prevent tissue damages due to oxidative stress. This study aimed to investigate the protective effect of water extract of Balinese purple sweet potatoes which contain high anthocyanins to the renal tissues of diabetic rats. A total of 30 adult male rats were divided into three groups using randomized post-test only control group design, respectivelly. Animals in group 1 (diabetic group) were given streptozotocin 60 mg/kg; group 2 (diabetic+extract/ treatment group) at 3 days after the animals were given streptozotocin they were given 4 mL per day of the extract for 50, group 3 (control group) animals were given placebo. At day 50 of the treatment, the blood and renal tissue superoxidase dismutase (SOD) and malondialdehyde (MDA), creatinin and blood urea nitrogen (BUN) level of all rats were measured. The data were analyzed using analysis of variance. The results showed a significant increase of blood and renal tissues MDA and BUN level in group 1 (p<0,05). In addition, a decrease of SOD and creatinin level (p<0,05) were also seen in this group. In comparison to animals in group 2, the increase of blood MDA and BUN level as well the decrease of SOD and, creatinin level were significantly lower (p<0,05). From these findings, it can be concluded that aqueous extract of Balinese purple sweet potato can prevent renal function disorders due to oxidative stress