EFFECTS RED DRAGON FRUIT (Hylocereus Polyrhizus) PEEL EXTRACT TOWARDS MALONDIALDEHYDE LEVEL IN Rattus Norvegicus Strain Wistar EXPOSURED BY CIGARETTE SMOKE

The peel of red dragon fruit (Hylocereus Polyrhizus) is known have content Flavonoid. Flavonoids in the red dragon fruit peel has the potential to be used as a natural antioxidants. This study aims to analyze the effect of red dragon fruit peel of Malondialdehyde (MDA) plasma level in wistar rats which were exposed to cigarette smoke. Thirty male rats, aged 2-3 months, weight ± 200g. Divided into 5 groups, K- (Normal), K + (Cigarette Smoke), P1 (Cigarette Smoke and Red dragon fruit peel extract 2g /cc), P2 (Cigarette Smoke and red dragon fruit peel extract 4 g /cc), and P3 (Cigarette Smoke and red dragon fruit peel extract 8 g /cc). Provision of red dragon fruit peel extract and exposure to cigarette smoke carried out for 14 days. The blood was taken on the 15th day and the levels of Malondialdehyde measurement done by the TBARS method. Doses of 2 g /cc, 4 g /cc, and 8 g /cc ethanol extract of red dragon fruit peel can lower MDA levels in wistar rat plasma that exposured cigarette smoke (p <0.05). The mean value of plasma MDA level of group K- is 0.237 , K+ is 0.317, P1 is 0.294 ,P2 is 0.275, dan P3 is 0.26