EN 
IN
Journal article
EFEK SINERGIS KOMBINASI CHLORHEXIDINE DAN ALKOHOL TERHADAP DAYA HAMBAT PERTUMBUHAN STAPHYLOCOCCUS AUREUS
Yosi Kusuma KOMANG JANUARTHA PUTRA PINATIH MADE AGUS HENDRAYANA
Volume : 8 Nomor : 3 Published : 2019, March
E - Jurnal Medika Udayana
Abstrak
Antiseptic are chemical substance that have the activity to eradicate microorganism or inhibit their activity, so that to prevent infection. One of the examples of antiseptic are chlorhexidine and alcohol. Chlorhexidine and alcohol have a similar mechanism, which is to disturb bacterial membrane resulting in lysis. The purpose of this research is to know whether there is a difference in antiseptic activity of chlorhexidine-alcohol combination with chlorhexidine or alcohol towards Gram positive and negative, and also weather there is a synergetic activity between those antiseptics. This research uses an experimental method, post-test only design, through disk diffusion test. The resulting data are inhibitory zone of alcohol, chlorhexidine, and chlorhexidine-alcohol combination for Staphylococcus aureus and Escherichia coli. The mean inhibitory zone for chlorhexidine-alcohol (19.56 ± 0.88SD) with alcohol (0) and chlorhexidine (18 ± 0.71SD) for Staphylococcus aureus is significantly larger, with a p= 0.002 for chlorhexidine; meanwhile for Escherichia coli, mean inhibitory zone for chlorhexidine-alcohol 16.22 ± 0.83SD, chlorhexidine 17.22 ± 2.05 SD, and alcohol 13.22 ± 4.08SD. The difference in diameter is only significant for alcohol (p=0.019), but not for chlorhexidine (p=0.387). Conclusion can be made that antiseptic activity are synergetic to chlorhexidine-alcohol combination for Staphylococcus aureus, but not to Escherichia coli.