Intake flavonoid glycosides of fruit Solanum betaceum in its activity as a Candidate of anti-stress oxidative

Objective: Oxidative stress due to an imbalance between free radicals and antioxidants in the body can be overcome by intake exogenous antioxidants, such as flavonoid glycoside constituent of Solanum betaceum. This study aims to prove the effect of flavonoid glycosides from an n-butanol extract of Solanum betaceum as an antioxidant. Methode: The experiment was done using a true experimental randomized completed with posttest only control group design. Twenty-four rats were divided into four groups, with each group containing six rats. Group 1 (Po) controlled, group 2 (P1), given maximum physical activity, group 3 (P2), given ethanol extract and maximum physical activity, group 4 (P3), given n-butanol extract and maximum physical activity. The maximum physical activity was achieved after swimming activity for 90 minutes/day for 5 days. The ethanol and n-butanol extract were administered orally at a dose of 50 mg /Kg BW /day for 5 days, respectively. After 5 days of treatment, all rats were then euthanasia to obtain their liver to be analyzed to obtain SOD and MDA data. All of the data were analyzed using ANOVA to obtain the treatment difference toward control by statistically with significance at level ? = 0,05. Result: Antioxidant activity test results on Wistar rats given maximum physical activity showed that the intake of ethanol and n-butanol extract of terong belanda at a dose of 50 mg /Kg BW caused higher SOD activity and significantly lower MDA levels (p?0.05) Conclusion: Based on the results of this study it can be concluded that the flavonoid glycoside extract of n- butanol terong belanda (Solanum betaceum) was proved can prevent oxidative stress through SOD thereby decreasing the level of MDA liver of Wistar rat. Keywords: Solanum betaceum Cav, SOD, MDA, liver Wistar rats