Hepatoprotective Activities of Girang Leaf Ethanol Extracts (Leea angulata Korth. Ex Miq) on Wistar Rats Induced by Paracetamol

Abstract: Paracetamol is an analgesic and antipyretic drug that has a toxic effect when it is used with excessive doses. The toxicity of paracetamol is caused by the formation of NAPQI reactive metabolites and paracetamol inducing the formation of free radicals which can cause liver cell damage. This study aims to test the hepatoprotective activity of ethanol extract of girang leaves (Leea angulata Korth. Ex Miq) in male white rats of the Wistar strain.Acute liver damage was done by inducing paracetamol at a dose of 750 mg / kg BW. Ethanol extract of girang leaves was given at a dose of 50, 100, 200, and 400 mg/kg per oral for 14 days. Liver biochemical parameters (ALT activity) of rat serum were measured by using a spectrophotometer. The results showed that the mean ALT activity of rat given girang leaves ethanol extract of 50 mg/kg BW (82.30 ± 12.06) U/L, 100 mg/kg BW (71.70 ± 2.86) U/L, 200 mg/kg BW (43.50 ± 1.56) U/L, and 400 mg/kg BW (42.90 ± 1.86) U/L significantly (p?0.05) lower than the mean of rat of ALT activity which was only induced by paracetamol (109.90 ± 12.06) U/L. The conclusion of this study is that ethanol extract of girang leaves has hepatoprotective activity by reducing the ALT activity of rats given excessive paracetamol with an effective dose of 200 mg/kg BW. Keywords: hepatoprotective effect, paracetamol, ethanol extract of girang leaves