Influence of Iron on Plasma Interleukin-2 and Gamma Interferon Level in Iron Deficiency Anemia

ABSTRACT Aim: to find out the the influence of iron on the levels of plasma IL-2 and IFN ? in iron deficiency anemia patient. Methods: the study subjects were patients with IDA (intended samples) selected from the accessible population that met the inclusion and exclusion criteria using consecutive sampling technique and by signing an informed consent. Blood samples were taken for measurement of IL-2 and IFN? concentrations as well as list of questionnaires for obtaining data on age, gender, body weight, infections suffered, use of immunosuppressive medicines, malnutrition, malignancy and genetic disorder, and IDA diagnosis. The levels of IL-2 and IFN? were measured before and after 8 weeks of iron tablet adminitration using immunoassay solid phase ELISA. Descriptive statistics was used to illustrate patient’s characteristics and frequency distribution of various variables. The average difference of IL-2 and IFN? concentrations was also examined pre and post administration of iron tablets for 8 weeks using Wilkoxon sign rank test. Results: in the study, 26 IDA patients were eligible,