Lupus is a chronic inflammatory disease that occurs as a result of an autoimmune disorder that occurs when a sufferer's immune system or immune system attacks his own cells, tissues, or organs. Normally, the immune system that protects the body from infection and various types of systemic lupus erythematosus (SLE) is a serious multisystem autoimmune disease. In this situation the body forms various types of antibodies, including antibodies to nuclear antigens (ANAs), causing damage to various organs. This disease presents with periods of remission and episodes of acute disease with a variety of features associated with the various organs involved. SLE is aimed at women aged 15-40 years during the reproductive period with a female to male ratio of 5: 1. Pregnancy with SLE can cause complications both to the mother and the fetus in its poor management. Complications that pregnant syringe of pregnancy with SLE usually occur in the mother are lupus flares, exacerbating decreased kidney function, worsening of hypertension symptoms, increasing the risk of preeclampsia, and complications to the fetus usually leading to miscarriage, preterm birth, and complications of neonatal lupus. Pregnancy with SLE should pay attention to pregnancy from pregnancy, pre-conception evaluation, pregnancy, and antenatal management. However, the immune system of people with lupus actually attacks healthy body cells.