ProWeiss is a probiotic powder containing 109-10 cfu / g of dried-living cells of Weissella confusa F213 strain originally from Indonesia. This product is developed with a microencapsulation technique with a unique formula containing skim milk and anti-clotting substances so that it can prevent cell damage due to the cooling process.Weissella confusa F213 is beneficial for gastrointestinal tract healthy through modulation of healthy bacteria in the digestive tract contributing to improve health such as improving the blood lipid profile, modulating immune system, preventing constipation and improving the digestive tract. In addition, this probiotic can also provide protection from pathogenic bacterial infections as well as the removal of pathogenic bacteria from GI tract, and can prevent damage due to T. gondii infection.ProWeiss contains a probiotic strain isolated from the gastrointestinal tract of healthy infants, and has unique characteristics as the Indonesian human digestive tract mostly consume plant-based food ingredients, instead of milk. This strain is not only able to improve the health of the digestive tract through modulation of the growth of endogenous bacteria in the digestive tract, but also has a strong ability to attach to epithelial cells so that it can survive in the digestive tract for a long time.The use of probiotics for the prevention and control of certain diseases is increasingly attracting attention. But, ironically most of the probiotic products currently circulating in the Indonesian market are imported products. On the other hand, the function of probiotics in improving aspects of human health is strongly influenced by the characteristics of individual strains. In addition, the benefits of probiotics are also determined by the ability of strains to adapt in the digestive tract of the host so that strains of foreign probiotics are not necessarily compatible with the conditions of the digestive tract of Indonesian with diets and types of food that are very different with those of foreigners. Based on the health benefits of strains that are specific to each strain, as well as aspects of compatibility between probiotic strains and host digestive tract conditions, it is strongly believed that ProWeiss probiotic powder is potential to substitute foreign probiotic products.ProWeiss passed the Technology Readiness Level (TRL) 7 and it is declared as Prototype Product of Universitas Udayana.